Ipamorelin Co
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Research compound, not FDA-approved

Ipamorelin is sold as the cleanest growth hormone peptide. Its real history is an abandoned drug program.

Novo Nordisk designed it in the 1990s as NNC 26-0161. It reached two phase 2 trials for postoperative gut recovery: the published one failed its endpoint (p = 0.15) and the 320-patient one was never published. FDA now lists ipamorelin acetate in Category 2 of its compounding lists over significant safety concerns. We document the whole record: the real selectivity data at its true grade, every human trial, and the rodent studies the marketed benefits actually come from.

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  • 33fetch-verified citations, 100% peer-reviewed, government or registry
  • 16studies in the graded evidence table, species labeled on every row
  • 3of those rows are human: one PK study and the two failed-or-unpublished ileus trials
  • 0human trials of the goals it is sold for: muscle, fat loss, anti-aging, recovery

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Compounded injectable treatmentPrepared after approval
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Important: Standalone ipamorelin is not sold through this checkout. The available option is a tesamorelin / ipamorelin blend.

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Prescription treatment requires an online medical evaluation. A provider will determine whether treatment is medically appropriate; approval is not guaranteed. Checkout and medical intake are provided by FormBlends and its contracted clinical, pharmacy, payment, and fulfillment providers. Ipamorelin Co is the referring educational publisher and does not make prescribing decisions.

Key facts

  • StatusResearch compound, not FDA-approved
  • Clearance0.078 L/h/kg (IV, healthy men)source
  • Volume of distribution0.22 L/kg at steady statesource
  • Gh peaksingle GH pulse peaking at 0.67 hours, then declining to negligible levelssource
  • Dose proportionalitydose-proportional over 4.21 to 140.45 nmol/kg IVsource
  • Animal kineticsrat: clearance 5-fold lower than GHRP-6, mainly intact urinary excretion, ~20% nasal bioavailabilitysource
  • Unstudiedno published human subcutaneous or multiple-dose kineticssource
  • ClassGhrelin-receptor (GHS-R1a) agonist; GHRP-family pentapeptideReview or guidelinesource
  • Half-lifeabout 2 hours (human, IV) hHuman PKsource
  • OriginNovo Nordisk drug candidate NNC 26-0161 (1998)Chemical referencesource
  • MoleculePentapeptide, C38H49N9O5, MW 711.9Chemical referencesource
  • Human trials1 PK study; 2 phase 2 ileus trials (1 failed, 1 unpublished)Registry recordsource
  • Efficacy trials for marketed usesNone exist in humansAbsence of evidencesource
  • WADAProhibited at all times (S2.2.4, named)Regulatory recordsource

Read the full Ipamorelin monograph

Browse by topic

Everything on Ipamorelin, organized the way you research it.

Comparisons17 articlesEvidence15 articlesDosing12 articlesSourcing10 articlesSafety7 articles

Free Ipamorelin tools

Practical calculators and references, each scoped and sourced.

T-01Reconstitution calculatorConcentration, draw volume, U-100 syringe units, and doses per vial from vial size, water volume, and dose.T-03Study dose explorerEvery dose reported in the published literature for this compound, filterable by species and route, each row sourced.

study rows by species, from the evidence table

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All guides

61 in-depth, individually cited guides.

Comparisons 17 guides

Ibutamoren vs ipamorelin: mechanism, evidence, and dosingIbutamoren is an oral ghrelin mimetic with a long half-life; ipamorelin is an injectable, more selective GH secretagogue. Here's what the research actually shows.Updated 2026-07-25Read guide →
Ipamorelin vs sermorelin: how the two GH peptides compareIpamorelin and sermorelin both raise GH but work on different receptors. Compare mechanism, selectivity, evidence, and practical differences here.Updated 2026-07-25Read guide →
AOD 9604 vs ipamorelin: mechanisms, evidence, and use casesAOD 9604 targets fat metabolism via a lipolytic HGH fragment; ipamorelin stimulates whole GH pulses via ghrelin receptor agonism. Here's how the evidence compares.Updated 2026-07-24Read guide →
CJC-1295, ipamorelin vs tesamorelin: how they actually differCJC-1295/ipamorelin and tesamorelin both raise GH via different receptors. Compare mechanism, evidence, and dosing logic before deciding what fits your goal.Updated 2026-07-24Read guide →
GHRP-2 vs ipamorelin: how the two GH secretagogues differGHRP-2 raises cortisol, prolactin, and appetite; ipamorelin is selective for GH. Here's what the receptor pharmacology and human data actually show.Updated 2026-07-24Read guide →
Hexarelin vs ipamorelin: how these two GH secretagogues differBoth hit the ghrelin receptor, but hexarelin is stronger and less selective. Compare mechanism, cortisol/prolactin effects, and evidence for each.Updated 2026-07-24Read guide →
Ipamorelin vs tesamorelin: how the two peptides actually differIpamorelin is a selective ghrelin mimetic; tesamorelin is a GHRH analog approved by FDA for HIV lipodystrophy. Here's how mechanism, evidence, and dosing compare.Updated 2026-07-24Read guide →
1 closely related:Ipamorelin vs tesamorelin: how the two peptides actually differ
Ipamorelin peptide vs tesamorelin peptide: how they differIpamorelin and tesamorelin work through different mechanisms. Compare receptor targets, evidence base, side effects, and why they're often combined.Updated 2026-07-24Read guide →
Ipamorelin vs CJC-1295: what actually differsIpamorelin and CJC-1295 hit different GH pathways (ghrelin mimetic vs GHRH analog). Here's the mechanism, evidence, and stacking logic, sourced from primary studies.Updated 2026-07-24Read guide →
Ipamorelin vs ghrp-6: mechanism, evidence, and dosing differencesBoth are ghrelin mimetics, but ipamorelin is receptor-selective and GHRP-6 spikes cortisol and appetite. Here's the actual receptor and trial data.Updated 2026-07-24Read guide →
Ipamorelin vs hexarelin: how the two secretagogues differIpamorelin is a selective GH secretagogue with minimal cortisol or prolactin effect; hexarelin is more potent but less selective. Full comparison and evidence.Updated 2026-07-24Read guide →
Ipamorelin vs hgh: how the two actually compareIpamorelin nudges your own pituitary to release GH in pulses; HGH injects the hormone directly. Here's what the research actually shows about each.Updated 2026-07-24Read guide →
Ipamorelin vs ibutamoren: mechanism, evidence, and risk comparedIpamorelin and ibutamoren both raise GH and IGF-1, but they differ in receptor selectivity, route, legal status, and side effect profile. Full comparison.Updated 2026-07-24Read guide →
Ipamorelin vs MK-677: how the two GH secretagogues differIpamorelin is a selective injectable GHRP; MK-677 is an oral ghrelin mimetic with a longer half-life. Compare mechanism, evidence, and side effect data here.Updated 2026-07-24Read guide →
MK-677 vs ipamorelin: mechanism, evidence, and safetyMK-677 is an oral ghrelin mimetic with a long half-life; ipamorelin is an injectable, more selective GH secretagogue. Here's what the research actually shows.Updated 2026-07-24Read guide →
Tesamorelin peptide vs ipamorelin: what's the difference?Tesamorelin is a GHRH analog, ipamorelin is a ghrelin mimetic. They hit different receptors and are often combined. Here's the mechanism-level comparison.Updated 2026-07-24Read guide →

Evidence 15 guides

How long does ipamorelin take to work?Ipamorelin raises growth hormone within about 15-30 minutes per dose. Real body composition changes take 8-12+ weeks. Here's the timeline, by evidence.Updated 2026-07-25Read guide →
Ipamorelin human studies: what the research actually showsA review of ipamorelin human studies: the 1998 discovery trial, PK/PD data, ileus trials, and where evidence ends and forum claims begin.Updated 2026-07-25Read guide →
Ipamorelin in women: what the research actually showsNo trial has isolated ipamorelin's effects in women. Here's what the underlying pituitary science, dosing logic, and safety questions look like for female use.Updated 2026-07-25Read guide →
Ipamorelin stacks: what the evidence actually saysIpamorelin is often paired with CJC-1295 or other peptides. Here's what's studied, what's folklore, and what a rational stack looks like.Updated 2026-07-25Read guide →
How to get ipamorelin: the legitimate routes explainedThere is no standalone ipamorelin product. Here's how it's actually dispensed, what's compounded vs. approved, and how to get it through a licensed provider.Updated 2026-07-24Read guide →
How to take ipamorelin: dosing, timing, injection basicsHow to take ipamorelin peptide: injection method, timing around meals and sleep, typical dose ranges from published research, and what the evidence actually covers.Updated 2026-07-24Read guide →
Ipamorelin: mechanism, evidence, and how it's actually dosedIpamorelin selectively triggers GH release via the ghrelin receptor, per a 1998 study in 22 subjects. Here's what's proven, what's folklore, and how it's dispensed.Updated 2026-07-24Read guide →
Ipamorelin: what animal studies show vs human evidenceIpamorelin has decades of rat, ferret, and cichlid data but almost no modern human trials. Here's exactly what's proven, what's inferred, and what's folklore.Updated 2026-07-24Read guide →
Ipamorelin before and after claims: what's real, what's forum loreIpamorelin before-and-after photos are everywhere. Here's what the actual human and animal studies show, and where the marketing outruns the evidence.Updated 2026-07-24Read guide →
Ipamorelin clinical trials: what the human data actually showsIpamorelin has real Phase 1-2 human trials plus decades of rat and receptor work. Here's what was measured, in whom, and what's still forum lore.Updated 2026-07-24Read guide →
Ipamorelin mechanism of action, explained receptor by receptorHow ipamorelin triggers GH release through the GHS-R1a receptor, why it's called selective, and what 25+ years of research actually shows versus forum claims.Updated 2026-07-24Read guide →
Ipamorelin before and after: what the research actually showsWhat changes with ipamorelin peptide use, according to human and animal studies, and why most "before and after" claims online outrun the evidence.Updated 2026-07-24Read guide →
Ipamorelin results: what the research actually showsA rat-and-human evidence review of ipamorelin: GH release, ileus trials, bone data, and where the science stops and forum lore begins.Updated 2026-07-24Read guide →
Tesamorelin and ipamorelin stack: mechanism and evidenceTesamorelin adds GHRH signaling to ipamorelin's ghrelin-receptor pull. Here's what the peptide literature actually shows about stacking them, and what's folklore.Updated 2026-07-24Read guide →
What does ipamorelin actually do in the bodyIpamorelin selectively triggers pituitary growth hormone release without raising cortisol or prolactin. Here's what the peptide research actually shows, and what it doesn't.Updated 2026-07-24Read guide →

Dosing 12 guides

Does ipamorelin need to be refrigerated?Yes: reconstituted ipamorelin needs refrigeration and stays stable roughly 20-30 days. Here's the storage science, stability data, and what degrades it faster.Updated 2026-07-25Read guide →
Ipamorelin dosage: how much, how often, and whyIpamorelin dosage in clinical use runs 100-300 mcg per injection. Here's what the studies actually measured, plus how CJC-1295 stacking changes the math.Updated 2026-07-25Read guide →
Ipamorelin half life: how long it actually lastsIpamorelin's half life is roughly 2 hours in humans. Here's what that means for dosing frequency, injection timing, and why the PK data still has gaps.Updated 2026-07-25Read guide →
Ipamorelin how to inject: a practical protocol guideStep-by-step on drawing up, injecting, and rotating sites for ipamorelin, with dosing basics, timing, storage, and what the research actually supports.Updated 2026-07-25Read guide →
Ipamorelin injection sites: where and how to inject itSubcutaneous belly fat is the standard ipamorelin injection site. Here's the rotation schedule, needle depth, and what actually changes absorption.Updated 2026-07-25Read guide →
Ipamorelin timeline: what to expect week by weekIpamorelin's half-life is under an hour, but sleep and body-comp effects unfold over weeks to months. Here's the realistic timeline, backed by the actual studies.Updated 2026-07-25Read guide →
CJC-1295 and ipamorelin dosage calculator: how the math worksA CJC-1295/ipamorelin dosage calculator only converts mg to mL. Here's the actual math, typical research ranges, and why the studied doses vary so much.Updated 2026-07-24Read guide →
How to reconstitute ipamorelin: a step-by-step protocolIpamorelin ships as lyophilized powder that needs bacteriostatic water. Here's the exact reconstitution math, storage rules, and mistakes to avoid.Updated 2026-07-24Read guide →
Ipamorelin cycle length: how long should a cycle run?There's no FDA-approved ipamorelin cycle, but most clinical protocols run 8 to 12 weeks with reassessment. Here's what the actual studies (not forums) support.Updated 2026-07-24Read guide →
Ipamorelin dosage calculator: how the math actually worksThere's no FDA-approved ipamorelin dose to calculate from. Here's how research protocols set mcg/kg amounts, why calculators vary, and what to ask a provider.Updated 2026-07-24Read guide →
Ipamorelin storage and shelf life: what actually keeps it stableLyophilized ipamorelin keeps for years refrigerated or frozen; reconstituted, the practical window is about 2-4 weeks in the fridge. Details and sourcing here.Updated 2026-07-24Read guide →
How to reconstitute CJC-1295 and ipamorelin correctlyStep-by-step guide to reconstituting CJC-1295 and ipamorelin with bacteriostatic water: ratios, storage, stability, and mistakes that ruin peptides.Updated 2026-07-24Read guide →

Sourcing 10 guides

Ipamorelin certificate of analysis explained: what to checkA COA should show purity by HPLC, mass spec ID, and a batch number matched to your vial. Here's what a real ipamorelin COA contains and what fakes skip.Updated 2026-07-25Read guide →
Ipamorelin cost and pricing: what it actually runs and whyIpamorelin isn't sold alone. It's compounded with tesamorelin, priced per vial and month. Here's what drives the real cost and what to watch for.Updated 2026-07-25Read guide →
Ipamorelin legal status: is it legal to buy and use?Ipamorelin has no FDA-approved indication and is not sold as a standalone drug in the US. Here's what the law actually says, and what's real versus forum lore.Updated 2026-07-25Read guide →
Is ipamorelin fda approved? the honest regulatory answerNo. Ipamorelin has no FDA-approved drug application. It's available only through 503A/503B compounding pharmacies, unlike GH itself. Here's what that actually means.Updated 2026-07-25Read guide →
Best place to buy ipamorelin: a buyer's reality checkThere's no standalone ipamorelin product to buy legally. Here's what the research, the FDA rules, and pharmacy compounding actually allow.Updated 2026-07-24Read guide →
Buy ipamorelin: a reality check on price, legality, sourcingThinking about where to buy ipamorelin? Here's what the research actually shows, what it really costs, and why no legit source sells it alone.Updated 2026-07-24Read guide →
How to verify ipamorelin quality before you use itNo standalone ipamorelin SKU exists in reputable channels. Here's how to check purity, sourcing, and pharmacy legitimacy before you trust a vial.Updated 2026-07-24Read guide →
Ipamorelin compounding pharmacy vs research supplierA 503A/503B pharmacy dispenses ipamorelin under a prescription; a 'research supplier' sells unregulated peptide with no clinical oversight. Here's the real difference.Updated 2026-07-24Read guide →
Ipamorelin prescription requirements: what you actually needIpamorelin has no FDA-approved product and no standalone SKU. It's dispensed as a compounded tesamorelin/ipamorelin blend, and yes, you need a prescription.Updated 2026-07-24Read guide →
Ipamorelin purity and testing: what buyers actually need to knowThere is no FDA-approved standalone ipamorelin product to test against. Here's how purity claims work, what analysis actually shows, and what to ask before buying.Updated 2026-07-24Read guide →

Safety 7 guides

Ipamorelin and athlete drug testing: what actually gets caughtIpamorelin is a peptide banned by WADA. Here's how testing labs detect it, what the research shows, and why athletes should assume it's found.Updated 2026-07-25Read guide →
Ipamorelin contraindications: who should not use it, and whyIpamorelin is a research-stage GH secretagogue with no FDA-approved human indication. Here is what the animal and pharmacokinetic data actually say about risk.Updated 2026-07-25Read guide →
Ipamorelin drug interactions: what actually needs a lookReal interaction concerns for ipamorelin: insulin/diabetes meds, corticosteroids, opioids, and thyroid drugs. What's studied vs. forum guesswork.Updated 2026-07-25Read guide →
Ipamorelin long term side effects: what the evidence showsNo human trial has run past a few months, so long term ipamorelin side effects are mostly unstudied. Here's what the animal and short-term human data actually say.Updated 2026-07-25Read guide →
Ipamorelin and blood work: what to test and whenNo FDA-mandated labs exist for ipamorelin. Here's what IGF-1, glucose, and lipid panels can actually tell you, and how often to check them.Updated 2026-07-24Read guide →
Ipamorelin side effects: what the research actually showsInjection site redness, water retention, and cortisol shifts are the documented ipamorelin side effects. Here's what's studied vs. forum lore, dose by dose.Updated 2026-07-24Read guide →
Is ipamorelin safe? what the human and animal data showIpamorelin's own 1998 discovery study found it selective for GH release with no cortisol or prolactin spike. Here's what's tested and what isn't.Updated 2026-07-24Read guide →
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